崔红娟

1988-2000，于西南大学完成本科、硕士、博士学习；

2000-2001，第四军医大学博士后；

2001-2005，俄亥俄医学院生化及肿瘤生物学助理研究员；

2005-2009，俄亥俄医学院生化及肿瘤生物学助理教授；

2009-2010，美国克利夫兰研究诊所干细胞生物学及再生医学助理教授；

2010-2014，成为重庆市巴渝学者；

2010-至今，西南大学教授，家蚕基因组生物学国家重点实验室干细胞研究方向总负责人。

肿瘤生物学及肿瘤干细胞的研究。

家蚕、昆虫干细胞生物学发育及细胞生物学领域。
肿瘤药效评价及转化医学。

申请者2010年5月回国前在美国从事多年干细胞生物学研究， 着重探讨了肿瘤干细胞在肿瘤发生、形成上的机理，寻找肿瘤的特异性分子标志，就肿瘤干细胞的分子标记进行了原创性工作，发现和阐明了在肿瘤发生过程中原癌基因N-myc对干细胞的作用机理。并系统论证了多梳族转录因子在神经肿瘤干细胞的调控，为特异性阻断此通路进行优化治疗提供了可行性依据，为肿瘤的预后监控提供了新的重要检测指标。

回国后建立了家蚕干细胞生物学实验室，获得重庆市“巴渝学者”择优支持。以干细胞生物学作为家蚕基因组生物学国家重点实验室发展的重要支撑方向之一，着重研究家蚕各成体干细胞在变态发育的分子机制，开展家蚕组织、器官内干细胞的识别、维持及其多向分化调控研究。以家蚕开展人类疾病的模型的研制，实现从昆虫模型、到老鼠模型以及到人类疾病药效的转化研究。

近年在国内外重要期刊发表30篇以上，SCI文章20篇，影响因子超过100分，被SCI源文章广泛引用。主持和参加国内973课题与美国NIH基金、美国癌症研究协会重大科研项目多项。多次被相关国际学术会议选为执行主席和特邀报告人，共计获邀参加国际会议并做大会报告10次以上。并被多家杂志邀请为审稿人。在美国期间，先后主持和参与了NIH、美国癌症协会和俄亥俄州多项课题的研究。在Nature Cel. Bio.，J.Biol.Chem.，Am.J.Pathol.，Molcancer Ther.等国际著名杂志发表高水平学术论文10余篇。

1. Mao L, Ding J, Zha Y, Yang L, McCarthy B, King W,Hongjuan Cui, Ding H. HOXC9 links cell cycle exit and neuronal differentiation and is a prognostic marker in neuroblastoma.Cancer Res., 2011 Jun 15;71(12):4314-24. Epub 2011 Apr 20.
2. L Mao, J Ding, A Perdue, L Yang, Y Zha, M Ren, S Huang,Hongjuan Cuiand H-F Ding, Cyclin E1 is a common target of BMI1 and MYCN and a prognostic marker for neuroblastoma progression.Oncogene(2011) 1–11.
3. Gonit M, Zhang J, Salazar MD,Hongjuan Cui, Shatnawi A, Trumbly R, Ratnam M. Hormone depletion-insensitivity of prostate cancer cells is supported by the AR without binding to classical response elements.Mol Endocrinol.2011 Apr;25(4):621-34. Epub 2011 Feb 17.
4. Tai Li, Zhao-Bo Cui, Xiao-Xue Ke, Juan Tan, Fang-Fang Li, Ting Li, Xiang-Wei Wang, andHong-Juan Cui.Essential Role for p53 and Caspase-9 in DNA Damaging Drug-Induced Apoptosis in Neuroblastoma IMR32 Cells.DNA and Cell Biology, 2011 Dec;30(12):1045-50 Epub 2011 may 25.
5. Tai Li, Lin Wang, Xiao-xue Ke, Man Xu, Zhao-bo Cui,Hongjuan Cui,DNA damaging drugs-induced apoptosis sensitized byN-mycin neuroblastoma cells.Cell Biology International, (2012) 36, 331–337. Epub ahead of print, DOI 10.1042/CBI20110231.
6. Zhichuan Li, Zhongbing Zhang, Joe X. Xie, Xin Li, Jiang Tian,Hongjuan Cui,Hanfei Ding, Joseph I. Shapiro and Zijian Xie. Na/K-ATPase mimetic pNaKtide inhibits the growth of human cancer cells. 2011,Journal of Biological Chemistry,J Biol Chem.2011 Sep 16;286(37):32394-403. Epub 2011 Jul 22.
7. Xiangwei Wang, Lunshan Xu, Jianhua Wan, Xueyang Gong, Kui Zhang, Liang Yi, Zhonghuai Xiang, Minhui Xu,Hongjuan Cui. Sonic Hedgehog pathway is essential for neuroblastoma cell proliferation and tumor growth.MCBI,DOI 10.1007/s11010-011-1222-6.
8. Yang L,Hongjuan Cui, Wang Z, Zhang B, Ding J, Liu L, Ding HF. Loss of negative feedback control of nuclear factor-kappa B2 activity in lymphocytes leads to fatal lung inflammation.Am J pathol, 2010 Jun;176(6):2646-57. Epub 2010 Apr 2
9. Yang H, Zhu L, Ebraheim NA, Liu X, Castillo S, Tang T, Liu J,Hongjuan Cui.2009, Analysis of risk factors for recurrence after the resection of sacral chordoma combined with embolization.Spine J. 2009 Dec;9(12):972-80. Epub 2009 Oct 1.
10. Ling Mao, Yuan-Peng Xia, Yu-Nan Zhou, Ruo-Lian Dai, Xue Yang, Shu-Jie Duan, Xian Qiao, Yuan-Wu Mei, Bo Hu andHongjuan Cui, 2009 A critical role of Sonic Hedgehog signaling in maintaining the tumorigenicity of neuroblastoma cellsCancer Sci.2009 Oct;100(10):1848-55. Epub 2009 Jun 26,.
11. Goleeta Alam,Hongjuan Cui(co-principal author),Huilin Shi, Jane Ding, ling Mao, William A. Maltese, and Han-Fei Ding, MYCN promotes the expansion of Phox2B-positive neuronal progenitors to drive neuroblastoma development.Am J Pathol.2009 Aug; 175(2):856-66. Epub 2009 Jul 16.
12. Huilin Shi,Hongjuan Cui, Goleeta Alam, William Gunning, Andrea Nestor, David Giovannucci, Ming Zhang, Han-Fei Ding, 2008. Nestin expression defines both glial and neuronal progenitors in postnatal sympathetic ganglia,Journal of Comparative Neurology, 508: 867-878.
13. Hongjuan Cui, Bo Hu, Tai Li, Jun Ma, Goleeta Alam, William T Gunning, and Han-Fei Ding, 2007. Bmi-1 is essential for the tumorigenicity of Neuroblastoma cells,American Journal of Pathology, 170 (4): 1370-1378.
14. Hongjuan Cui, Jun Ma, Jane Ding, Tai Li, Goleeta Alam, and Han-Fei Ding, 2006, Bmi-1 regulates differentiation and clonogenic self-renewal of I-type neuroblastoma cells in a concentration-dependent manner,Journal of Biological Chemistry, 281 (45): 34696-34704.
15. Hongjuan Cui, Tai Li, Han-Fei Ding, 2005, Linking of N-Myc to death receptor machinery in neuroblastoma cells,Journal of Biological Chemistry, 280: 9474-9481.
16. Yongqing Wang,Hongjuan Cui (Co-principal author), Allen Schroering, Jane L. Ding, William S. lane, Gaël McGill, David E. Fisher and Han-Fei Ding. 2002. NF-ĸB2 p100 is a pro-apoptotic protein with anti-oncogenic function.Nature Cell Biology. 4(11): 888-93。
17. Hongjuan Cui, Allen Schroering, and Han-Fei Ding. 2002. p53 mediated DNA damaging drug-induced apoptosis through a caspase-9-dependent pathway in Sh-SY5Y neuroblastoma cells.Molecular Cancer Therapeutics. 1: 679-686。