魏文胜

中文名魏文胜

毕业院校美国斯坦福大学

目录导航

重要经历

教育经历：

1999 - 2004，博士后，遗传学，Stanford Unversity

1995 - 1999，理学博士，遗传学，Michigan State University

1987 - 1991，理学学士，生物化学，北京大学

工作经历：

2016 — 研究员，北京未来基因诊断高精尖创新中心（ICG）

2015 — 研究员，北大-清华生命科学联合中心（CLS）

2014 — 研究员，北京大学生物医学集成创新研究所（BIOPIC）

2007 — 研究员，北京大学生命科学学院，生化与分子生物学

2005 — 2007 Research Associate，美国斯坦福大学医学院遗传学系

1999 — 2004 博士后，美国斯坦福大学医学院遗传学系

科研领域

研究领域：

真核基因组编辑及高通量功能基因组学，疾病与感染的分子机制。

研究方向：

着重发展和应用基因组编辑技术，涵盖编码及非编码序列的高通量功能基因组学、生物动态光学成像及精准医疗。在此基础上，特别关注宿主细胞参与病原微生物感染的分子机制，为发展宿主导向的治疗手段提供新的药物靶点和思路。

代表性论文

1. Ren Q, Li C, Yuan P, Cai C, Luo G, Zhang L and Wei W , A Dual-Reporter System for Real-Time Monitoring and High-throughput CRISPR/Cas9 Library Screening of the Hepatitis C Virus , Sci. Rep. , 2015 , 5, 8865; DOI:10.1038/srep08865 , [Abstract] , [Full Text]

2. Peng J, Zhou Y, Zhu S and Wei W , High-throughput Screens in Mammalian Cells Using the CRISPR-Cas9 System , FEBS Journal , 2015 , DOI: 10.1111/febs.13251 , [Abstract] , [Full Text],State-of-the-Art Review

3. Shen J, Cai C, Yu Z, Pang Y, Zhou Y, Qian L, Wei W and Huang Y , A microfluidic live cell assay to study anthrax toxin induced cell lethality assisted by conditioned medium , Sci. Rep. , 2015 , 5, 8651; DOI:10.1038/srep08651 , [Abstract] , [Full Text]

4. Yuan P, Zhang H, Cai C, Zhu S, Zhou Y, Yang X, He R, Li C, Guo S, Li S, Huang T, Feng H and Wei W , Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B , Cell Res. , 2015 , 25:157–168 , [Abstract] , [Full Text], published online 30 December 2014 (Cover story)

5. Ding Y, Su S, Tang W, Zhang X, Chen S, Zhu G, Liang J, Wei W, Liu L, Chen Y-G, Wu W , S-G2 phase enriched β-catenin/TCF complex ensures survival and cell cycle progression , Journal of Cell Science , 2014 , 127(22):4833-45. doi: 10.1242/jcs.146977. Epub 2014 Sep 18. , [Abstract] , [Full Text]

6. Coco Chu, Yifeng Wang, Xu Zhang, Xinya Ni, Junxia Cao, Wan Xu, Zhongjun Dong, Pengfei Yuan, Wensheng Wei, Yuanwu Ma, Lianfeng Zhang, Longyan Wu, and Hai Qi , SAP-regulated T cell-APC adhesion and ligation-dependent and -independent Ly108-CD3ζ interactions , Journal of Immunology , 2014 , 193(8):3860-71. doi: 10.4049/jimmunol.1401660. Epub 2014 Sep 12. , [Abstract] , [Full Text]

7. Zhou Y, Zhu S, Cai C, Yuan P, Li C, Huang Y and Wei W , High-throughput Screening of a CRISPR/Cas Library for Functional Genomics in Human Cells , Nature , 2014 , 509:487-91 , [Full Text],(AOP)

8. Qian LL, Cai CZ, Yuan PF, Jeong SY, Yang XZ, Almeida VD, Ernst J, Costa M, Cohen SN, and Wei WS , Bidirectional effect of Wnt signaling antagonist DKK1 on the modulation of anthrax toxin uptake , Sci China Life Sci , 2014 , 57:469–481 , [Full Text],Cover

9. Yang J, Zhang Y, Yuan P, Cai C, Ren Q, Guo S, Zhu C, Qi H and Wei W , A Complete Decoding of DNA Recognition by TAL Effector RVDs , Cell Res. , 2014 , 24:628-631 , [Full Text]

10. Yang J, Yuan P, Wen D , Sheng Y, Zhu S, Yu Y, Gao X and Wei W , ULtiMATE system for rapid assembly of customized TAL effectors , PLoS One , 2013 , 8:e75649 , [Abstract] , [Full Text]

11. Lih C, Wei W, and Cohen SN. , Txr1: a transcriptional regulator of thrombospondin-1 that modulates cellular sensitivity to taxanes. , Genes Dev. , 2006 , 20, 2082-2095. , [Abstract] , [Full Text]

12. Wei W, Lu Q, Chaudry J, Leppla S, and Cohen SN. , The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin. , Cell , 2006 , 124, 1141-1154. , [Abstract] , [Full Text]

13. Lu Q, Wei W, Kowalski P, Chang A, and Cohen SN , EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin , Proc. Natl. Acad. Sci. USA , 2004 , 101, 17246-51 , [Abstract] , [Full Text]

14. Wei W, Plovanich Jones A, Deng W, Jin Q, Collmer A, Huang H, and He SY , The gene coding for the Hrp pilus structural protein is required for type III secretion of Hrp and Avr proteins in Pseudomonas syringae pv. tomato , Proc. Natl. Acad. Sci. USA , 2000 , 97, 2247-52 , [Full Text]

15. Roine E, Wei W*, Yuan J, Nurmiaho-Lassila EL, Kalkkinen N, Romantschuk M, He SY , Hrp pilus: an hrp-dependent bacterial surface appendage produced by Pseudomonas syringae pv. tomato DC3000 , Proc. Natl. Acad. Sci. USA , 1997 , 94, 3459-64 , [Full Text],(*Co-first author)

16. Gopalan S, Wei W, and He SY , hrp gene-dependent induction of hin1: a plant gene activated rapidly by both harpins and the avrPto gene-mediated signal. , Plant J. , 1996 , 10, 591-600. , [Abstract]