徐彦辉

1995-1999年，学士，清华大学生物科学与技术系

1999-2004年，博士，清华大学生物科学与技术系，饶子和教授（中科院院士）实验室。

2004-2008年，博士后，普林斯顿大学分子生物学系，施一公教授（中科院院士）实验室。徐彦辉

2008.01-2008.10，副研究员，复旦大学生物医学研究院。

2008.10-2017.03，研究员，复旦大学生物医学研究院。

2010.01-2017.03，双聘教授，复旦大学附属肿瘤医院。

2017.04，研究员，复旦大学附属肿瘤医院；双聘教授，复旦大学生物医学研究院。^[3]

利用生化和结构生物学方法研究表观遗传调控及转录相关蛋白质发挥功能的分子机制，并开展靶向药物开发。

研究DNA甲基化的建立（DNMT1， DNMT3），识别（UHRF1）和去除（TET1/2/3）相关蛋白的催化，底物识别及酶活性调节的分子机制，DNA甲基化与组蛋白甲基化之间相互调节的机制以及RNA甲基化修饰蛋白的相关研究。徐彦辉

肿瘤发生的机制研究，从表观遗传（组蛋白去甲基化酶，DNA甲基化调控蛋白），信号通路（Hippo，mTOR）的角度研究其关键蛋白的结构与功能，发现其调节肿瘤发生发展的分子机制，揭示可能存在的药物靶点。利用结构研究获得的信息，开展了基于结构的药物设计，筛选和优化工作，开发用于研究或临床（抗肿瘤）的化合物。

代表论文

*通讯作者，# 共同第一作者徐彦辉

1. Zheng, H., Qi, Y., Hu, S., Cao, X., Xu, C., Yin, Z., Chen, X., Li, Y., Liu, W., Li, J., Wang, J., Wei, G., Liang, K.,Chen, F. X.*, andXu, Y.*(2020) Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase.Science370, eabb5872

2. He, S., Wu, Z., Tian, Y., Yu, Z., Yu, J., Wang, X.,Li, J., Liu, B., andXu, Y.*(2020) Structure of Nucleosome-bound human BAF Complex.Science367: 875-881

3.Hu, L.#, Li, Z.#, Cheng, J.#, Rao, Q., Gong, W., Liu, M., Shi, YG., Zhu, J., Wang, P. andXu, Y.*(2013) Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation,Cell155, 1545-1555

4.Hu L, Lu J, Cheng J, Rao Q, Li Z, Hou H, Lou Z, Zhang L, Li W, Gong W, Liu M, Sun C, Yin X, Li J, Tan X, Wang P, Wang Y, Fang D, Cui Q, Yang P, He C, Jiang H, Luo C*,Xu, Y.*Structural insight into substrate preference for TET-mediated oxidation.Nature. 2015 Nov 5;527:118-22.

5.Guo, X., Wang, L., Li, J., Ding, Z., Xiao, J., Yin, X., He, S., Shi, P., Dong, L., Li, G., Tian, C., Wang, J., Cong, Y., andXu, Y.*(2015) Structural insight into autoinhibition and histone H3-induced activation of DNMT3A.Nature517, 640-644

6.Yang Y, Yin X, Yang H,Xu, Y.*(2015)Histone Demethylase LSD2 Acts as an E3Ubiquitin Ligase and Inhibits Cancer Cell Growth through Promoting Proteasomal Degradation of OGT.Molecular Cell58, 47-59

7.Cheng J, Yang H, Fang J, Ma L, Gong R, Wang P, Li Z,Xu Y.*(2015) Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation.Nat Commun.6:7023

8.Fang J, Cheng J, Wang J, Zhang Q, Liu M, Gong R, Wang P, Zhang X, Feng Y, Lan W, Wong J, Yang H, Cao C,Xu, Y.*Hemi-methylated DNA Opens a Closed Conformation of UHRF1 to Facilitate Its Histone Recognition.Nat Commun.7:11197.

9.Zhu, L., Li, L., Qi, Y., Yu, Z., andXu, Y.*(2019) Cryo-EM structure of SMG1-SMG8-SMG9 complex.Cell research29, 1027-1034

10.Xiao, J., Liu, M., Qi, Y., Chaban, Y., Gao, C., Pan, B., Tian, Y., Yu, Z., Li, J., Zhang, P., andXu, Y.*(2019) Structural insights into the activation of ATM kinase.Cell research29, 683-685

11.Chen, X., Liu, M., Tian, Y., Li, J., Qi, Y., Zhao, D., Wu, Z., Huang, M., Wong, C. C. L., Wang, H. W., Wang, J.*, Yang, H.*, andXu, Y.*(2018) Cryo-EM structure of human mTOR complex 2.Cell research28, 518-528

12.Rao, Q., Liu, M., Tian, Y., Wu, Z., Hao, Y., Song, L., Qin, Z., Ding, C., Wang, H. W.*, Wang, J*, andXu, Y.*(2018) Cryo-EM structure of human ATR-ATRIP complex.Cell research28, 143-156

13.Yin, X., Liu, M., Tian, Y., Wang, J., andXu, Y.*(2017) Cryo-EM structure of human DNA-PK holoenzyme.Cell research27, 1341-1350

14.Yang, Y.#, Hu, L.#, Wang, P.#, Hou, H., Lin, Y., Liu, Y., Li, Z., Gong, R., Feng, X., Zhou, L., Zhang, W., Dong, Y., Yang, H., Lin, H., Wang, Y., Chen, C. D.*, andXu, Y.*(2010) Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans,Cell research20, 886-898.

15.Li, Z.#, Zhao, B.#, Wang, P., Chen, F., Dong, Z., Yang, H., Guan, K. L.*, andXu, Y.*(2010) Structural insights into the YAP and TEAD complex,Genes & development24, 235-240.

16.Gong, R.#, Li, L.#, Liu, Y.#, Wang, P., Yang, H., Wang, L., Cheng, J., Guan, K. L., andXu, Y.*(2011) Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation,Genes & development25, 1668-1673.^[3]