张志荣

1982年毕业于四川医学院药学专业，获学士学位。

1993年毕业于华西医科大学，获理学博士学位。

1993年任华西医科大学副教授、药学院副院长。

1997年任教授，1998年1月聘为博士研究生导师。

1999年1月任药学院院长兼药物研究所所长。

1999年获得国家杰出青年科学基金资助。

主要学术兼职：

-国务院学位委员会药学学科评议组成员（第五、六届）。

-国家973计划健康科学领域专家咨询组专家。

-国家药典委员会执行委员暨药用辅料与药包材专业委员会主任。

-普通高等医药院校“十三五”药学类规划教材（科学出版社）专家委员会主任。

-全国高等医药院校药学类规划教材（中国医药科技出版社）编写委员会副主任。

-全国高等学校药学专业教材（人民卫生出版社）第四、五届评审委员会副主任。

-全国高等医学教育学会药学教育研究会副理事长。

-四川省药学会理事长。

-《华西药学杂志》、《中国药剂学杂志》（网络版）主编；《中草药》、《中国药学年鉴》副主编；《药学学报》、《中国药学杂志》、《中国抗生素杂志》、《中国医药工业杂志》、《Asian Journal of Pharmaceutical Sciences》等10余个杂志编委。

⒈ 药物与治疗基因传递系统研究； 靶向药物研究。

在药物传递系统特别是靶向给药系统及新药开发研究等方面做了一些有价值的工作。近10年来，负责国家杰出青年科学基金项目1项，国家自然科学基金重点项目1项，国家自然科学基金面上项目5项，国家“863”计划课题2项，国家“十五”重大科技专项“创新药物与中药现代化”项目1项，教育部、四川省重点项目3项，其他部省级项目10余项。主编、副主编出版专著、教材、参考书8部。发表论文280余篇，其中SCI、EI收录60余篇。主研、参研新药12个。申请发明专利9项。

⒈血管内注射高分子材料及其肝靶向纳米粒基础研究。国家自然科学基金重点项目（批准号：30430770），2005.1—2008.12。

2．张志荣负责，肾近端小管细胞靶向前体药物的研究。国家自然科学基金项目（批准号：30430770），2006.1—2008.12。

⒊药物新剂型新制剂的应用基础研究。成都康弘科技实业（集团）公司合作项目（2003年~2015年），600万元。

⒈ Hong-Wei Zhang,Ling Zhang,Xun Sun and Zhi-Rong Zhang*,Successful transfection of hepatoma cells after encapsulation of plasmid DNA into negatively charged liposomes. Biotechnology and Bioengineering,2007;96⑴：118-124.

⒉ Jie Liu,Tao Gong,Changguang Wang,Zhirong Zhong,Zhirong Zhang?. Solid lipid nanoparticles loaded with insulin-sodium cholate complex: preparation and characterization. International Journal of Pharmaceutics,2007;340⑻：153-162。

⒊ Fu Chen,Zhi-Rong Zhang* and Yuan Huang*. Evaluation and modification of N-trimethyl chitosan chloride nanoparticles as protein carriers. International Journal of Pharmaceutics,2007;336:166-173.

⒋ Zhi-xiang Yuan,Xun Sun*,Tao Gong,Hong Ding,Fu Chen,Zhi-rong Zhang*. Randomly 50% N-acetylated low molecular weight chitosan as a novel renal targeting carrier. Journal of Drug Targeting.2007,15⑷：269-278.

⒌ Zheng Qiang,Ye Limin,Gao Rong,Xiong Meijin,Han Jing,Gong Tao,Zhang Zhirong*. Kinetic release of triptolide after injection of renal targeting 14-succinyl triptolide-lysozyme in rat kidney study by liquid chromatography/mass spectrometry. Biomedical Chromatography,2007;21:724-729. IF=1.611.

⒍ Yu Nie,Wen-Min Yuan,Tao Gong,Yao Fu,Zhi-Rong Zhang*. Investigation on characterization and transfection of a novel multi- polyplex gene delivery system. Journal of Applied Polymer Science.2007;106⑵：1028-1033.

⒎ Yourong Duan,Yan Zhang,Tao Gong,Zhirong Zhang*. Synthesis and Characterization of MeO-PEG-PLGA- PEG-OMe Copolymers as Drug Carriers and Their Degradation Behavior in Vitro. Journal of Materal Sciences-Materals in Medicine.2007;18:2067- 2073.

⒏ Rong Gao,Qiang Zheng,Tao Gong,Yao Fu,Li Deng,and Zhirong Zhang*. Gradient high-performance liquid chromatography for the simultaneous determination of Chlorogenic Acid and Baicalin in plasma and its application in the study of pharmacokinetics in rats. Journal of Pharmaceutical and Biomedical Analysis. 2007；43：335-340.

⒐ Juan Huang,Tao Gong,Zhi-Rong Zhang*. Synthesis and Characterization of Insulin- 5-Fu Conjugate,Enabling Insulin as Multi-drug Carrier via a Dendritic Approach. Chinese Chemical Letters. 2007;18:247-250.

⒑ Zhi-Rong ZHONG,Ji LIU,Yong DENG,Zhi-Rong ZHANG*,Qin He*. Preparation and characterization of a novel non-viral gene transfer system,Procationic-Liposome- Protamine-DNA complexes (PLPD). Drug Delivery. 2007,14⑶：177-183.

⒒ Zhi-Rong Zhong,Zhi-Rong Zhang*，Ji Liu,Yong Deng,Qin He*. Construction of TK/GCV administration system mediated by transferrin modified pro-cationic liposomes . Pharmazie，2007；62:522-527.

⒓ Xiuli Wang,Zhirong Zhang,Hualin Fu,Qian Chen,Liu Jie,Yu Nie,Li Deng,Tao Gong*. Simultaneous determination and pharmacokinetics study of water-soluble and lipid-soluble components of Danshen in rat plasma using HPLC-UV method. Biomedical Chromatography,2007;21:1180-1185.

⒔ Zhi-Rong Zhong,Zhi-Rong Zhang，Ji Liu,Yong Deng,Qin He*.Characteristics comparison before and after lyophilization of transferrin modified Procationic- Liposome-Protamine-DNA complexes (Tf-PLPD). Archives of Pharmacal Research,2007;30⑴：102-108.

⒕ Xuan Qin,Dan Zhou,Zhi-rong Zhang,Yuan Huang*. Determination of bergenin in rat plasma by high-performance liquid chromatography. Pharmazie,2007;62⑸：323-326.

⒖ 张志荣主编。全国高等医药院校药学类规划教材 药剂学 ，北京：高等教育出版社，2007年12月。^[1]

1. Xiawei Wei*, Bin Shao, Zhiyao He, Tinghong Ye, Min Luo, Yaxiong Sang, Xiao Liang, Wei Wang, Shuntao Luo, Shengyong Yang, Changyang Gong, Maling Gou, Hongxing Deng, Yinglan Zhao, Hanshuo Yang, Chengjian Zhao, Li Yang, Zhiyong Qian, Xun Sun, Jiahuai Han, Chengyu Jiang, Shuang Zhang, Min Wu, Zhirong Zhang*. Cationic Nanocarriers Induce Cell Necrosis through Impairment of Na+/K+-ATPase and Cause Subsequent Inflammatory Response.Cell Research, 2015; 25:1-17. doi:10.1038/cr2015.9, IF=12.413.

2.Jianbo Li*, Jinjie Zhang*, Yao Fu, Xun Sun, Tao Gong, Zhirong Zhang**. Dual-specific targeting therapy mediated by a phenolic propanediamine moiety for local and systemic complications of acute pancreatitis.Journal of Controlled Release，2015;212:19-29.IF=7.705。

3. Ting Zhang, Qiang Peng, Fenying San, Mengxin Wang, Wenqi Wu, Tao Gong*, Zhirong Zhang*. Sustained delivery of peptides and proteins by high content phospholipids-based phase separation gel.Biomaterials, 2015;45:1-9. IF=8.557.

4. Qi Wang, Peifeng Liu, Ying Sun, Tao Gong, Mingjie Zhu, Xun Sun, Zhirong Zhang*,Yourong Duan*. Preparation and properties of biocompatible PS-PEG/ Calcium phosphate nanospheres.Nanotoxicology, DOI:10.3109/17435390.2014. 911381. IF=7.336。

5. Cheng Yan*; Zhu Biyue; Deng Yue; Zhang Zhirong*. In Vivo Detection of Cerebral Amyloid Fibrils with Smart DCM-Based Fluorescence Probe.Analytical Chemistry, 2015;87(9):4781-4787. doi: 10.1021/acs.analchem.5b00017. IF=5.825.

6.Yanping Li, Yangyang Zhou, Jiang, Jiayu; Xinyi Wang, Yao Fu, Tao Gong, Xun Sun, Zhirong Zhang*. Brain-targeting mechanism of dexibuprofen prodrugs modified with ethanolamine-related structures.Journal of Cerebral Blood Flow and Metabolism. 2015 00,1-10,doi:10.1038/jcbfm.2015.160, IF=5.407.

7. Xinyi Wang, Jianbo Li, Chaoqun Xu, Yanping Li, Tao Gong, Xun Sun, Yao Fu, Qin He, Zhirong Zhang*. Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil.Bioconjugate Chemistry, 2014,doi:10.1021/bc5004108,IF=4.821.

8. Yuxuan Zhu, Xun Sun, Tao Gong, Qin He, Zhirong Zhang*. Antioxidant and antiapoptotic effects of 1,1'-(biphenyl-4,4'-diyl)-bis(3- (dimethylamino)-propan -1-one) protect PC12 cells from Aβ-induced injury.Molecular Pharmaceutics. 2014,11,428-435 . IF=4.787。

9. Yanping Li; Yangyang Zhou; Bowen Qi; Gong Tao; Xun Sun; Yao Fu; Zhi-Rong Zhang*. Brain-specific delivery of dopamine mediated by N,N-dimethyl amino group for the treatment of Parkinson’s disease.Molecular Pharmaceutics. 2014, doi.org/10.1021/mp500352pl. IF=4.787.

10.Xiaohong Wang, Menghua Xiong, Yingchun Zeng, Xun Sun, Tao Gong, Zhirong Zhang*. A new conjugate: MGC in attenuating renal Ischemia/Reperfusion Injury.Molecular Pharmaceutics. 2014, doi.org/10.1021/mp500282g, IF=4.787.

11.Jingjie Zhang, Tao Gong*, Zhirong Zhang*. Mechanism of enhanced oral absorption of morin by phospholipid complex based self-nanoemulsifying drug delivery system.Molecular Pharmaceutics. doi.10.1021/mp5005806, IF=4.787。

12.Xu Song, Qing Lin, Ling Guo, Yao Fu, Jianfeng Han，Huan Ke, Xun Sun, Tao Gong*, Zhirong Zhang*. Rifampicin loaded mannosylated cationic nanostructured lipid carriers for dual-targeting to alveolar macrophages.Pharmaceutical Resaerch.2014,doi:10. 1007/s11095-014-1572-3,IF=3.952.

13.Jingxin Mo, Lee Yong Lim* and Zhirong Zhang*L-carnitine Ester of Prednisolone: Pharmacokinetic and pharmacodynamic evaluation of a Type I Prodrug.International Journal Pharmaceutics. 2014;475:e123-e129. IF=3.785。

14.Qin Zhang, Yao Fu, Renhe Liu, Tao Gong, Xun Sun, Zhi-Rong Zhang*. Renal-specific delivery of Prednisolone-folate conjugates for renal ischemia/ reperfusion injury.RSCAdvanceds, 2014(4):50828～50831.IF=3.708.

15.Man Li, Zhen Liang, Xun Sun, Tao Gong*, Zhirong Zhang*. A Polymeric Prodrug of 5-Fluorouracil-1-Acetic Acid Using a Multi-Hydroxyl Polyethylene Glycol Derivative as the Drug Carrier.Plos One, 2014,9(11):e112888. IF=3.534.

16.Peng Zhou, Xun Sun, Tao Gong, Zhirong Zhang*, Ling Zhang*. Conjugating glucosamine to triptolide to enhance its protective effect against renal ischemia- reperfusion injury and reduce its toxicity.Journal of drug targeting，2014; 22(3): 200-210.IF=2.723.

17.Qi Wang, Pei Liu, Peifeng Liu, Tao Gong, Suming Li, Yourong Duan*, Zhirong Zhang*. Preparation, blood coagulation and cell compatibility evaluation of chitosan-graft-polylactide copolymers.Biomedical Materials, 9(2014)015007 (11pp), doi:10.1088/1748-6041/9/1/015007, IF=2.923。

18.Qing Lin, Liqin Ling, Ling Guo, Jinjie Zhang, Tao Gong, Xun Sun, Zhirong Zhang*. Molecular property and intestinal absorption characteristics of imperialinein vitroandin situ. Acta Pharmacol Sinca,2015;36:863-873. doi:10.1038/aps. 2015.27, IF=2.912。

19.张志荣主编，“十二五”普通高等教育本科国家级规划教材、全国高等学校药学类规划教材《药剂学》（第二版），高等教育出版社，2014，北京。^[2]